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Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells.

J Ethnopharmacol. 2018;

Yeo Emilia Tze Ying，Wong Kelly Wang Ling，See Mun Ling，Wong Ka Yan，Gan Sook Yee，Chan Elaine Wan

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摘要

Piper sarmentosum Roxb. (PS)， belonging to Piperaceae family， is an edible plant with medicinal properties. It is traditionally used by the Malays to treat headache and boost memory. Pharmacological studies revealed that PS exhibits anti-inflammatory， anti-oxidant， anti-acetylcholinesterase， and anti-depressant-like effects. In view of this， the present study aimed to investigate the anti-inflammatory actions of PS and its potential neuroprotective effects against beta-amyloid (Aβ)-induced microglia-mediated neurotoxicity.